Host-Microbe Systems Assembly
We investigate the factors that shape the composition of host-associated microbial communities and assess the relative contributions of selective filtering by the host environment, interactions between microbes, and stochastic processes in community assembly.
Host-Microbe Systems Dynamics
We use light sheet microscopy to characterize the spatial and temporal dynamics of microbial and host cells and genes during the establishment of host-associated microbial communities.
Host-Microbe Systems Evolution
We study the variation of host- associated microbial communities across genetically diverse populations of hosts to uncover the genetic determinants that shape the composition of resident microbial communities.
Cores & Hubs of Innovation
We pioneer methods to rear germ-free or axenic fish as animal models to study host-microbe interactions. In addition we curate collections of host- associated microbes and develop genetic tools and resources to study their biology.
We are innovating the use of light sheet microscopy to study the dynamics of host-microbe interactions on temporal and spatial scales that are relevant to microbes.
We harness the power of next generation sequencing to explore the diversity of host-associated microbial communities, host transcriptional responses to these communities, and host genetic variation associated with these communities.
We draw on sampling theory, spatial biodiversity theory, and probabilistic approaches to analyze highly complex sequence and image data and to model host-microbe systems.